Who Cannot Have Polynucleotides?
Who Cannot Have Polynucleotides?
Content of this Paper
↑
Polynucleotides are increasingly used in aesthetics for their skin-rejuvenating effects, from improving hydration to supporting collagen production. While many people are suitable candidates, these treatments are not right for everyone.
Certain medical conditions, allergies, and health factors can make polynucleotides unsafe or less effective. Knowing who should avoid them is just as important as understanding their benefits. Before starting any treatment, a consultation with a qualified professional is essential to determine whether polynucleotides are appropriate for you.
%20(6).png)
Key Takeaways
- Not everyone is a suitable candidate for polynucleotide treatments.
- Consult your healthcare professional regarding your medical history.
- Specific health conditions may act as contraindications for polynucleotide treatment.
- Allergies or sensitivities can impact eligibility for aesthetic treatments.
- A thorough assessment can help mitigate risks associated with procedures.
Understanding Polynucleotides: What Are They and Their Uses?
Polynucleotide injections have gained significant attention in the realm of aesthetic and medical treatments due to their unique properties and multiple applications. Derived primarily from fish, such as salmon and trout, these injectables are sterile products integrated into a polymerised gel. Their ability to act as biostimulators makes them valuable in promoting cellular regeneration and enhancing skin quality.
What Are Polynucleotides?
Essentially, polynucleotides consist of long chains of nucleotides that exhibit numerous benefits for skin rejuvenation. These naturally occurring molecules play an important role in cellular processes, signalling your skin cells to produce collagen and elastin.
Such proteins are vital for maintaining the skin's elasticity and overall appearance. This biotechnological innovation opens doors to a variety of injectable treatments aimed at improving skin condition.
How Polynucleotides Are Used in Aesthetic and Medical Treatments
Polynucleotides are valued for their regenerative properties, making them useful across both aesthetic and medical settings. They work by improving hydration, stimulating collagen production, and supporting tissue repair. This versatility allows practitioners to address a wide range of concerns, offering patients natural-looking results without the need for invasive surgery.
Common uses include:
- Reducing fine lines and wrinkles: Softens signs of ageing by improving skin elasticity.
- Treating skin laxity: Restores firmness and a more youthful appearance.
- Enhancing hydration: Improves moisture retention for smoother, healthier skin.
- Improving skin texture: Promotes collagen synthesis, resulting in supple, refreshed skin.
- Minimising scarring: Supports tissue repair for acne scars or other types of scarring.
Common Indications for Polynucleotide Treatments
Polynucleotide treatments are becoming increasingly popular in aesthetic procedures, primarily due to their impressive ability to enhance skin quality. Common indications for these treatments include skin rejuvenation aimed at aged, acne prone and damaged skin, where fine lines and wrinkles often present significant concerns.
The regenerative properties of polynucleotides contribute to their effectiveness in restoring skin elasticity, making them a go-to choice for individuals wanting to improve overall skin hydration. Targeted regions, particularly around the eyes and neck, benefit from these treatments as they tend to show signs of ageing earlier than other areas.
- Skin rejuvenation: Targets aged and damaged skin to help restore a more youthful appearance.
- Reduction of fine lines: Works to minimise the appearance of fine lines and wrinkles.
- Enhancement of skin elasticity: Improves the firmness and natural elasticity of the skin.
- Overall hydration: Boosts skin moisture levels for a healthier, plumper complexion.
With these common indications, polynucleotides stand out as a viable option for enhancing skin quality and achieving a more youthful appearance.
Medical Conditions That May Prevent Polynucleotide Use
Understanding the conditions that may affect your treatment options is crucial, especially when considering polynucleotide therapies. Certain medical conditions can lead to polynucleotide ineligibility due to potential risks and complications. Below are key considerations related to specific categories of health issues.
Autoimmune Diseases and Immunocompromised Patients
If you have autoimmune diseases or are immunocompromised, polynucleotide treatments may not be suitable. Your body's immune response could react unpredictably to the polynucleotide injections. This heightened sensitivity increases the risk of side effects and complications, which can adversely affect your wellbeing.
Allergies and Sensitivities to Polynucleotide Components
Individuals with known allergies to any components of polynucleotides should refrain from these treatments. Fish derivatives are common in some formulations, and a history of allergic reactions can complicate medical outcomes. Making your healthcare provider aware of these sensitivities is essential when discussing treatment options.
Chronic Illnesses and Medications That Affect Suitability
Chronic illnesses, such as uncontrolled diabetes or blood disorders, may render you unsuitable for polynucleotide treatments. Additionally, medications that influence blood clotting or immune response can further complicate your treatment suitability. A thorough assessment of your health profile and current medications is necessary before proceeding with any polynucleotide therapies.
- Autoimmune diseases: May cause unpredictable immune responses; consultation with a specialist is recommended before treatment.
- Allergies: Can increase the risk of severe allergic reactions; patients should be tested for sensitivities beforehand.
- Chronic illnesses: May heighten the risk of complications; underlying conditions should be closely monitored.
- Medications: Can influence treatment outcomes; a full review with a healthcare provider is advised prior to proceeding.
Contraindications for Polynucleotide Treatments
When considering polynucleotide treatments, understanding the contraindications is essential for ensuring your safety and suitability for treatment. Certain conditions and situations may compel you to forgo these aesthetic treatments temporarily.
Pregnancy and Breastfeeding Considerations
During pregnancy and breastfeeding, it is generally recommended to avoid polynucleotide treatments due to insufficient research on their safety in these sensitive phases. While the evidence is not definitive, postponing cosmetic procedures is a common practice to safeguard both mother and child.
Skin Infections and Active Inflammation
Individuals with skin infections, open wounds, or active inflammation in the treatment area should delay polynucleotide treatments. Introducing injectables in the presence of such concerns could lead to complications and worsen the existing conditions, making it imperative to address these issues prior to any aesthetic procedures.
Recent Surgeries or Trauma Near Treatment Area
If you have undergone recent surgeries or have experienced trauma near the intended treatment area, you must exercise caution about receiving polynucleotide injections. Allowing time for recovery is crucial to avoid interfering with the healing process, which enhances the likelihood of safe and effective results from future treatments.
Age and General Health Factors Affecting Polynucleotide Eligibility
Your eligibility for polynucleotide treatments can largely depend on age considerations and overall health status. Age can significantly impact the effectiveness and suitability of these treatments.
For instance, young individuals without particular skin conditions may not find polynucleotide therapies ideal. In such cases, alternative, less invasive treatments are often more appropriate.
Age Limits or Considerations
When evaluating polynucleotide treatment eligibility, age limits are essential aspects. Younger patients may experience skin treatment outcomes that differ from those of older individuals. If you are under 18, practitioners may recommend exploring age-appropriate treatments focused on safety and efficacy.
Comorbidities and General Health Impact
Comorbidities such as chronic respiratory diseases, cardiovascular issues and other significant health concerns could impact your candidacy for polynucleotide treatments. The presence of these conditions may affect overall health and influence how your body responds to the treatment.
It's important to engage in a thorough consultation with a healthcare provider to assess how your general health can shape polynucleotide treatment eligibility. This comprehensive approach ensures that health factors do not compromise potential treatment benefits.
How to Determine If You Are a Suitable Candidate for Polynucleotides
Before undergoing treatment, consider the following points:
- Review your medical history with a qualified professional to identify any underlying conditions.
- Check for allergies or sensitivities that could affect treatment safety.
- Discuss any current medications or health conditions that might influence healing or outcomes.
- Ensure you are in overall good health, as this supports recovery and treatment effectiveness.
- Be open and transparent about your health background to reduce the chance of complications.
- Take time to weigh potential benefits against risks with your practitioner.
At the Institute of Medical Physics, our specialists provide in-depth consultations and personalised care, helping patients determine whether polynucleotide injections are the right choice for their skin health and rejuvenation goals.
Before You Go...
Polynucleotides are an exciting advancement in skin rejuvenation, but they are not suitable for everyone. Understanding the health conditions, allergies, and lifestyle factors that may prevent their use is key to making safe and informed choices. By consulting a qualified professional, you can be confident that any treatment plan is tailored to your individual needs.
At the Institute of Medical Physics, our team helps patients explore whether polynucleotide injections are the right option for them, always prioritising safety and natural-looking results.
If you’d like to learn more, we invite you to continue reading our related articles below, where you can explore other aspects of polynucleotides, their benefits, and alternative treatments.
Read More
- How quickly do polynucleotides work?
- What are the side effects of polynucleotide injections?
- Are polynucleotides painful?
About Institute of Medical Physics
The Institute of Medical Physics, founded by Dr. Emanuel Paleco, is a premier medical laboratory specialising in Medical and Aesthetic Laser Science.
With a flagship clinic in King’s Cross and additional locations in North London and Essex, the Institute is at the forefront of laser science innovation. Experience advanced laser science and innovative medical treatments.
Book a consultation with Dr. Emanuel Paleco and his expert team at the Institute of Medical Physics.
FAQs
Who cannot have polynucleotide treatments?
Individuals with autoimmune diseases, allergies to components in polynucleotide formulations, chronic illnesses, or those on specific medications affecting blood clotting should avoid these treatments. Pregnant or breastfeeding women and those with active skin infections or recent surgeries should also refrain from using polynucleotides.
What are polynucleotides?
Polynucleotides are injectable, sterile products derived from fish, particularly salmon or trout. They are known as biostimulators as they promote cellular regeneration by signalling skin cells to produce collagen and elastin, which are vital for maintaining skin elasticity and overall quality.
How are polynucleotides used in aesthetic and medical treatments?
Polynucleotides are widely used in aesthetic medicine to enhance skin hydration, stimulate collagen production, and address skin issues such as wrinkles, fine lines, and skin laxity. They may also improve the appearance of scars, crepey skin, and stretch marks.
What are the common indications for polynucleotide treatments?
Common indications include skin rejuvenation for aged and damaged skin, reduction of fine lines and wrinkles, enhancement of skin elasticity, and overall skin hydration improvements, especially in treatment areas like around the eyes and neck.
What conditions may prevent someone from using polynucleotides?
Conditions that may prevent suitability for polynucleotide treatments include autoimmune diseases, immunocompromised states, and known allergies to components derived from fish. Chronic illnesses such as uncontrolled diabetes or blood disorders can also affect eligibility.
What considerations should pregnant or breastfeeding women keep in mind regarding polynucleotides?
Pregnant and breastfeeding women are generally advised to avoid polynucleotide treatments due to the lack of comprehensive studies addressing their safety during these sensitive periods, despite no unequivocal evidence of harm.

Who Cannot Have Polynucleotides?
Polynucleotides are increasingly used in aesthetics for their skin-rejuvenating effects, from improving hydration to supporting collagen production. While many people are suitable candidates, these treatments are not right for everyone.
Certain medical conditions, allergies, and health factors can make polynucleotides unsafe or less effective. Knowing who should avoid them is just as important as understanding their benefits. Before starting any treatment, a consultation with a qualified professional is essential to determine whether polynucleotides are appropriate for you.

%20(6).png)
Key Takeaways
- Not everyone is a suitable candidate for polynucleotide treatments.
- Consult your healthcare professional regarding your medical history.
- Specific health conditions may act as contraindications for polynucleotide treatment.
- Allergies or sensitivities can impact eligibility for aesthetic treatments.
- A thorough assessment can help mitigate risks associated with procedures.
Understanding Polynucleotides: What Are They and Their Uses?
Polynucleotide injections have gained significant attention in the realm of aesthetic and medical treatments due to their unique properties and multiple applications. Derived primarily from fish, such as salmon and trout, these injectables are sterile products integrated into a polymerised gel. Their ability to act as biostimulators makes them valuable in promoting cellular regeneration and enhancing skin quality.
What Are Polynucleotides?
Essentially, polynucleotides consist of long chains of nucleotides that exhibit numerous benefits for skin rejuvenation. These naturally occurring molecules play an important role in cellular processes, signalling your skin cells to produce collagen and elastin.
Such proteins are vital for maintaining the skin's elasticity and overall appearance. This biotechnological innovation opens doors to a variety of injectable treatments aimed at improving skin condition.
How Polynucleotides Are Used in Aesthetic and Medical Treatments
Polynucleotides are valued for their regenerative properties, making them useful across both aesthetic and medical settings. They work by improving hydration, stimulating collagen production, and supporting tissue repair. This versatility allows practitioners to address a wide range of concerns, offering patients natural-looking results without the need for invasive surgery.
Common uses include:
- Reducing fine lines and wrinkles: Softens signs of ageing by improving skin elasticity.
- Treating skin laxity: Restores firmness and a more youthful appearance.
- Enhancing hydration: Improves moisture retention for smoother, healthier skin.
- Improving skin texture: Promotes collagen synthesis, resulting in supple, refreshed skin.
- Minimising scarring: Supports tissue repair for acne scars or other types of scarring.
Common Indications for Polynucleotide Treatments
Polynucleotide treatments are becoming increasingly popular in aesthetic procedures, primarily due to their impressive ability to enhance skin quality. Common indications for these treatments include skin rejuvenation aimed at aged, acne prone and damaged skin, where fine lines and wrinkles often present significant concerns.
The regenerative properties of polynucleotides contribute to their effectiveness in restoring skin elasticity, making them a go-to choice for individuals wanting to improve overall skin hydration. Targeted regions, particularly around the eyes and neck, benefit from these treatments as they tend to show signs of ageing earlier than other areas.
- Skin rejuvenation: Targets aged and damaged skin to help restore a more youthful appearance.
- Reduction of fine lines: Works to minimise the appearance of fine lines and wrinkles.
- Enhancement of skin elasticity: Improves the firmness and natural elasticity of the skin.
- Overall hydration: Boosts skin moisture levels for a healthier, plumper complexion.
With these common indications, polynucleotides stand out as a viable option for enhancing skin quality and achieving a more youthful appearance.
Medical Conditions That May Prevent Polynucleotide Use
Understanding the conditions that may affect your treatment options is crucial, especially when considering polynucleotide therapies. Certain medical conditions can lead to polynucleotide ineligibility due to potential risks and complications. Below are key considerations related to specific categories of health issues.
Autoimmune Diseases and Immunocompromised Patients
If you have autoimmune diseases or are immunocompromised, polynucleotide treatments may not be suitable. Your body's immune response could react unpredictably to the polynucleotide injections. This heightened sensitivity increases the risk of side effects and complications, which can adversely affect your wellbeing.
Allergies and Sensitivities to Polynucleotide Components
Individuals with known allergies to any components of polynucleotides should refrain from these treatments. Fish derivatives are common in some formulations, and a history of allergic reactions can complicate medical outcomes. Making your healthcare provider aware of these sensitivities is essential when discussing treatment options.
Chronic Illnesses and Medications That Affect Suitability
Chronic illnesses, such as uncontrolled diabetes or blood disorders, may render you unsuitable for polynucleotide treatments. Additionally, medications that influence blood clotting or immune response can further complicate your treatment suitability. A thorough assessment of your health profile and current medications is necessary before proceeding with any polynucleotide therapies.
- Autoimmune diseases: May cause unpredictable immune responses; consultation with a specialist is recommended before treatment.
- Allergies: Can increase the risk of severe allergic reactions; patients should be tested for sensitivities beforehand.
- Chronic illnesses: May heighten the risk of complications; underlying conditions should be closely monitored.
- Medications: Can influence treatment outcomes; a full review with a healthcare provider is advised prior to proceeding.
Contraindications for Polynucleotide Treatments
When considering polynucleotide treatments, understanding the contraindications is essential for ensuring your safety and suitability for treatment. Certain conditions and situations may compel you to forgo these aesthetic treatments temporarily.
Pregnancy and Breastfeeding Considerations
During pregnancy and breastfeeding, it is generally recommended to avoid polynucleotide treatments due to insufficient research on their safety in these sensitive phases. While the evidence is not definitive, postponing cosmetic procedures is a common practice to safeguard both mother and child.
Skin Infections and Active Inflammation
Individuals with skin infections, open wounds, or active inflammation in the treatment area should delay polynucleotide treatments. Introducing injectables in the presence of such concerns could lead to complications and worsen the existing conditions, making it imperative to address these issues prior to any aesthetic procedures.
Recent Surgeries or Trauma Near Treatment Area
If you have undergone recent surgeries or have experienced trauma near the intended treatment area, you must exercise caution about receiving polynucleotide injections. Allowing time for recovery is crucial to avoid interfering with the healing process, which enhances the likelihood of safe and effective results from future treatments.
Age and General Health Factors Affecting Polynucleotide Eligibility
Your eligibility for polynucleotide treatments can largely depend on age considerations and overall health status. Age can significantly impact the effectiveness and suitability of these treatments.
For instance, young individuals without particular skin conditions may not find polynucleotide therapies ideal. In such cases, alternative, less invasive treatments are often more appropriate.
Age Limits or Considerations
When evaluating polynucleotide treatment eligibility, age limits are essential aspects. Younger patients may experience skin treatment outcomes that differ from those of older individuals. If you are under 18, practitioners may recommend exploring age-appropriate treatments focused on safety and efficacy.
Comorbidities and General Health Impact
Comorbidities such as chronic respiratory diseases, cardiovascular issues and other significant health concerns could impact your candidacy for polynucleotide treatments. The presence of these conditions may affect overall health and influence how your body responds to the treatment.
It's important to engage in a thorough consultation with a healthcare provider to assess how your general health can shape polynucleotide treatment eligibility. This comprehensive approach ensures that health factors do not compromise potential treatment benefits.
How to Determine If You Are a Suitable Candidate for Polynucleotides
Before undergoing treatment, consider the following points:
- Review your medical history with a qualified professional to identify any underlying conditions.
- Check for allergies or sensitivities that could affect treatment safety.
- Discuss any current medications or health conditions that might influence healing or outcomes.
- Ensure you are in overall good health, as this supports recovery and treatment effectiveness.
- Be open and transparent about your health background to reduce the chance of complications.
- Take time to weigh potential benefits against risks with your practitioner.
At the Institute of Medical Physics, our specialists provide in-depth consultations and personalised care, helping patients determine whether polynucleotide injections are the right choice for their skin health and rejuvenation goals.
Before You Go...
Polynucleotides are an exciting advancement in skin rejuvenation, but they are not suitable for everyone. Understanding the health conditions, allergies, and lifestyle factors that may prevent their use is key to making safe and informed choices. By consulting a qualified professional, you can be confident that any treatment plan is tailored to your individual needs.
At the Institute of Medical Physics, our team helps patients explore whether polynucleotide injections are the right option for them, always prioritising safety and natural-looking results.
If you’d like to learn more, we invite you to continue reading our related articles below, where you can explore other aspects of polynucleotides, their benefits, and alternative treatments.
Read More
- How quickly do polynucleotides work?
- What are the side effects of polynucleotide injections?
- Are polynucleotides painful?
About Institute of Medical Physics
The Institute of Medical Physics, founded by Dr. Emanuel Paleco, is a premier medical laboratory specialising in Medical and Aesthetic Laser Science.
With a flagship clinic in King’s Cross and additional locations in North London and Essex, the Institute is at the forefront of laser science innovation. Experience advanced laser science and innovative medical treatments.
Book a consultation with Dr. Emanuel Paleco and his expert team at the Institute of Medical Physics.
FAQs
Who cannot have polynucleotide treatments?
Individuals with autoimmune diseases, allergies to components in polynucleotide formulations, chronic illnesses, or those on specific medications affecting blood clotting should avoid these treatments. Pregnant or breastfeeding women and those with active skin infections or recent surgeries should also refrain from using polynucleotides.
What are polynucleotides?
Polynucleotides are injectable, sterile products derived from fish, particularly salmon or trout. They are known as biostimulators as they promote cellular regeneration by signalling skin cells to produce collagen and elastin, which are vital for maintaining skin elasticity and overall quality.
How are polynucleotides used in aesthetic and medical treatments?
Polynucleotides are widely used in aesthetic medicine to enhance skin hydration, stimulate collagen production, and address skin issues such as wrinkles, fine lines, and skin laxity. They may also improve the appearance of scars, crepey skin, and stretch marks.
What are the common indications for polynucleotide treatments?
Common indications include skin rejuvenation for aged and damaged skin, reduction of fine lines and wrinkles, enhancement of skin elasticity, and overall skin hydration improvements, especially in treatment areas like around the eyes and neck.
What conditions may prevent someone from using polynucleotides?
Conditions that may prevent suitability for polynucleotide treatments include autoimmune diseases, immunocompromised states, and known allergies to components derived from fish. Chronic illnesses such as uncontrolled diabetes or blood disorders can also affect eligibility.
What considerations should pregnant or breastfeeding women keep in mind regarding polynucleotides?
Pregnant and breastfeeding women are generally advised to avoid polynucleotide treatments due to the lack of comprehensive studies addressing their safety during these sensitive periods, despite no unequivocal evidence of harm.


By -
Dr. Emanuel Paleco, PhD
October 7, 2025